O mai padme hū is the six-syllabled Sanskrit mantra particularly associated with the four-armed Avalokiteshvara (Tibetan Chenrezig, Chinese Guanyin), the bodhisattva of compassion. Mani means "jewel" or "bead" and Padma means "the lotus flower", the Buddhist Sacred Flower. Literally "the jewel in the flower".

"Thus the six syllables, OM MANI PADME HUM, mean that by the practice of a path which is an indivisible union of method and wisdom, you can transform your impure body, speech, and mind into the pure exalted body, speech, and mind of a Buddha" -HH the Dalai Lama